I hope I don't regret recommending this, but I read David Markson's The Last Novel a couple years ago (I think AndrewDill and I discussed this one) and in some ways it's comparable to Joyce in terms of its ability to alienate readers, but there are other more tangible/emotional things happening in the prose that don't make sense until the very end of the book, and when it all does come together it's very powerful and memorable, for me anyway, and I don't usually read that kind of thing.